Regenerative Medicine
Demonstrated Tissue
Regeneration
in Preclinical Models
Heart • Kidney • Liver • Pancreas • Brain
Evidence-Informed
Bench models validated through structured experimental and translational pathways, emphasizing reproducibility, safety, and biological fidelity.
Bench-to-Bedside Discipline
Dr. Ravishankar Polisetty’s regenerative medicine framework follows a rigorous bench-to-bedside approach: defining biological problems, demonstrating regeneration in controlled models, validating micro-architecture and functional recovery, and translating findings into safety-bounded clinical pathways (I-Prism).
Preclinical Regeneration Demonstrations
Heart
In experimental rat models of post-myocardial infarction, Dr. Polisetty demonstrated subtotal regeneration of cardiac tissue, including structural restoration, using his proprietary translational methodology.
Kidney
In partial nephrectomy animal models, renal tissue regeneration was successfully demonstrated, whereas no regeneration was observed following total nephrectomy—highlighting the biological limits and specificity of the regenerative process.
Liver
Using a clinically derived methodology, complete liver regeneration was demonstrated in subtotal hepatectomy models, with clear evidence of hepatic structural restoration.
Pancreas
In subtotal pancreatectomy animal models, total pancreatic regeneration was demonstrated, representing a first-of-its-kind achievement globally in experimental regenerative research.
Brain
In models of hypoxic-ischemic brain injury leading to coagulative necrosis, application of Dr. Polisetty’s proprietary mineral-based clinical methodology resulted in complete neuronal tissue regeneration, demonstrated for the first time in the world.
Down to the Micro-Architecture
Regeneration assessment extends beyond gross morphology, emphasizing restoration of native tissue planes, cellular organization, micro-structural integrity, and architecture consistent with physiological norms.
Where This Is Headed
A scalable, evidence-building regenerative framework integrated with clinical delivery platforms and institutional collaborations — converting regenerative science into operational medicine.